Nutrition and Metabolism Clinic (Pediatric)

The Nutrition and Metabolism Clinic treats children as hospitalised patients and outpatients.  Its activity is concentrated in two major areas: 

  • Nutrition (specific needs of the growing child, adapting these needs to the underlying illness)   
  • Hereditary diseases of the metabolism

Our specialities

The clinic is a Belgian reference centre for the treatment of hereditary diseases of the metabolism, that is, diseases affecting the metabolism of small molecules, complex molecules or energy production. The team is trained in therapeutic education out of a desire to enable the patient and his or her family to take ownership of their care.     To ensure it always remains at the forefront of scientific and medical knowledge of these rare diseases, the clinic cooperates closely with national and international university centres.   

  • The clinic's nutrition activities are the following:   
  • Systematic screening of infantile malnutrition of all patients hospitalised at the HUDERF and treatment if required 
  • Consultation for patients suffering from malnutrition  
  • Nutritional support for children with chronic pathologies influencing diet and/or weight gain.   
  • Consultation for children with dietary aversions, orality problems or dietary behaviour problems.   
  • Consultation for children with a cerebral motor infirmity or neuromuscular pathology    
  • Being developed: consultation for children with a vegetarian or vegan diet or for sports-playing children

Our Team


Our medical specialists



The Metabolism and Nutrition Clinic is active within European networks such as MetabERN (European Reference Network for rare or low prevalence complex diseases). It has also established strong links with the ULB's Paediatrics Laboratory and the ULB and VLB Brightcore Laboratory.   



The clinic is involved in research projects on the following subjects: 

Participation in European registers to improve knowledge of these diseases and determine new treatment protocols   (E-IMD, EHOD, galnet, etc.) 

  • Tyrosinaemia 
  • Improving neonatal screening 
  • Treatments using enzyme replacement 
  • Orality problems in patients with metabolic diseases 


Lien vers Array

Recommendations for the management of tyrosinaemia type 1

  • Authors : C De Laet, C Dionisi-Vici, J Leonard, P McKiernan, G Mitchell, L Monti, H Ogier de Baulny, G Pintos-Morell, U Spiekerkötter.
  • Journal : Orphanet J Rare Dis 2013, Jan 11;8:8.doi:10.1186/1750-1172-8-8. 
Lien vers Array

Evaluation of nutritional care of hospitalized children in a tertiary pediatric hospital

  • Authors : De Longueville C, Robert M, Debande M, Podlubnai S, Defourny S, Namane SA, Pace A, Brans C, Cayrol E, Goyens P, De Laet C.
  • Journal : Clin Nutr ESPEN. 2018 Jun;25:157-162. doi: 10.1016/j.clnesp.2018.02.008 
Lien vers Array

Long-term safety and outcomes in hereditary tyrosinaemia type 1 with nitisinone treatment: a 15-year non-interventional, multicentre study

  • Authors : Spiekerkoetter U, Couce ML, Das AM, De Laet C, Dionisi-Vici C, Lund AM, Schiff M, Spada M, Sparve E, Szamosi J, Vara R, Rudebeck M.
  • Journal : Lancet Diabetes Endocrinol. 2021 Jul;9(7):427-435. doi: 10.1016/S2213-8587(21)00092-9. Epub 2021 May 21. PMID: 34023005. 


Lien vers Array

Galactokinase deficiency: lessons from the GalNet registry

  • Authors : Rubio-Gozalbo ME, Derks B, Das AM, Meyer U, Möslinger D, Couce ML, Empain A, Ficicioglu C, Juliá Palacios N, De Los Santos De Pelegrin MM, Rivera IA, Scholl-Bürgi S, Bosch AM, Cassiman D, Demirbas D, Gautschi M, Knerr I, Labrune P, Skouma A, Verloo P, Wortmann SB, Treacy EP, Timson DJ, Berry GT.
  • Journal : Genet Med. 2021 Jan;23(1):202-210. doi: 10.1038/s41436-020-00942-9.